PowerEdge R650xs Supported Devices

Internal drive bay and hot-plug backplane:
Up to 16 x 2.5” HDD: SAS, SATA, Near-line SAS SSD: SAS, SATA 
Up to 12 x 3.5” HDD: SAS, SATA, Near-line SAS SSD: SAS, SATA 

Chassis with up to 16 x 2.5" drives with up to 8 NVMe also available.

Datasheet: R650xs spec sheet